13FPulse
SY

SYRE SPYRE THERAPEUTICS INC

2026Q2 · CUSIP 00773J202 · Sector: Healthcare & Biotech

Piling in

Net holder growth ranks near the top of the market

Funds that own it
260
Institutions that reported holding it to the SEC
Net increase in holders
+64
Last quarter 196 → now 260
How unusual is that
Top 5%
Stronger buying than 96% of US stocks
What the filings say, in one paragraph

260 funds held SYRE at the end of 2026Q2, up 64 from the quarter before. That is stronger buying than 96.3% of US stocks — among the most piled-into names this quarter. SYRE has had 4 buying rushes in its history, and the price moved +18.2% on average over the six months after (that is the raw price move, not how much it beat the market by). It sits in the Healthcare & Biotech sector.

How many funds owned it, quarter by quarter

Bars = net change in institutional holders, positive (green) or negative (red). Line = total institutional holders.

2023Q4: holders=54 2024Q1: holders=101 2024Q2: holders=107 2024Q3: holders=119 2024Q4: holders=131 2025Q1: holders=129 2025Q2: holders=128 2025Q3: holders=135 2025Q4: holders=153 2026Q1: holders=196 2026Q2: holders=260 -64 -32 +0 +32 +64 48161273 23Q424Q124Q224Q324Q425Q125Q225Q325Q426Q126Q2 Net change in holders (bars) Total funds holding (line)

What happened after each past buying rush 4 times in its history

Quarter of the rush How unusual then Price, next 3 months Price, next 6 months
2026Q2 Top 5%
2026Q1 Top 10% +23.6%
2024Q1 Top 5% -32.6% -26.3%
2023Q4 Top 20% +52.4% +62.8%

These are the raw price moves, not how much it beat the market by. Compare them against the market over the same months — in a strong bull market almost everything is up.

Show all the numbers (large funds, value held, options…) ▾
Of them, large funds
139
Change in large funds
+34
Total value they hold
$8.5B
Funds buying for the first time
90
Funds that sold out entirely
26
Price change that quarter
+24.2%
Funds holding puts (bearish)
4
Funds holding calls (bullish)
4

These are for people who want to dig. Skip them if they do not mean anything to you — the three numbers above are enough.

8,697 institutions have filed for this quarter. 13F permits late filing and a small number arrive in the weeks after the deadline, so the holder counts and changes below may tick up.

Email me the next update

2026 Q3 holdings are due 2026-11-16. We will email you when the refreshed lists are live.