13FPulse
IO

IONS IONIS PHARMACEUTICALS INC

2026Q2 · CUSIP 462222100 · Sector: Healthcare & Biotech

Normal

Fund flows are within the usual range

Funds that own it
504
Institutions that reported holding it to the SEC
Net increase in holders
+12
Last quarter 492 → now 504
How unusual is that
Above average
Stronger buying than 73% of US stocks
What the filings say, in one paragraph

504 funds held IONS at the end of 2026Q2, up 12 from the quarter before. Fund flows are within the usual range — nothing unusual. On the business itself, revenue over the last 12 months was $874M(YoY -7.4%), return on equity is -128.5%. IONS has had 11 buying rushes in its history, and the price moved +9.9% on average over the six months after (that is the raw price move, not how much it beat the market by). It sits in the Healthcare & Biotech sector.

How many funds owned it, quarter by quarter

Bars = net change in institutional holders, positive (green) or negative (red). Line = total institutional holders.

2016Q1: holders=310 2016Q2: holders=278 2016Q3: holders=277 2016Q4: holders=307 2017Q1: holders=270 2017Q2: holders=291 2017Q3: holders=296 2017Q4: holders=314 2018Q1: holders=326 2018Q2: holders=308 2018Q3: holders=320 2018Q4: holders=328 2019Q1: holders=388 2019Q2: holders=393 2019Q3: holders=372 2019Q4: holders=392 2020Q1: holders=361 2020Q2: holders=375 2020Q3: holders=367 2020Q4: holders=382 2021Q1: holders=365 2021Q2: holders=336 2021Q3: holders=324 2021Q4: holders=341 2022Q1: holders=334 2022Q2: holders=350 2022Q3: holders=349 2022Q4: holders=339 2023Q1: holders=315 2023Q2: holders=303 2023Q3: holders=313 2023Q4: holders=365 2024Q1: holders=359 2024Q2: holders=357 2024Q3: holders=353 2024Q4: holders=356 2025Q1: holders=343 2025Q2: holders=365 2025Q3: holders=436 2025Q4: holders=494 2026Q1: holders=492 2026Q2: holders=504 -71 -35.5 +0 +35.5 +71 243387530 16Q117Q218Q319Q421Q122Q223Q324Q426Q126Q2 Net change in holders (bars) Total funds holding (line)

What happened after each past buying rush 11 times in its history

Quarter of the rush How unusual then Price, next 3 months Price, next 6 months
2025Q4 Top 10% -9.7%
2025Q3 Top 5% +13.5% +2.5%
2025Q2 Top 20% +64.7% +89.3%
2023Q4 Top 10% -16.0% +7.2%
2023Q3 Top 20% -8.6% -20.2%
2022Q2 Top 10% -0.8% -13.1%
2019Q1 Top 5% +2.5% -14.3%
2018Q3 Top 20% +6.8% +27.6%

These are the raw price moves, not how much it beat the market by. Compare them against the market over the same months — in a strong bull market almost everything is up.

Show all the numbers (large funds, value held, options…) ▾
Of them, large funds
231
Change in large funds
+16
Total value they hold
$14.2B
Funds buying for the first time
69
Funds that sold out entirely
57
Price change that quarter
-15.4%
Funds holding puts (bearish)
15
Funds holding calls (bullish)
24

These are for people who want to dig. Skip them if they do not mean anything to you — the three numbers above are enough.

8,697 institutions have filed for this quarter. 13F permits late filing and a small number arrive in the weeks after the deadline, so the holder counts and changes below may tick up.

Fundamentals

PE (TTM)
EPS (TTM)
$-3.46
EPS YoY
Revenue (TTM)
$0.9B
Revenue YoY
-7.4%
Net margin
-64.7%
ROE
-128.5%
Debt ratio
85.3%
FCF (TTM)
-$561M
Dividend (TTM)
No dividend
Quarterly Revenue & EPS
2022-09-30: EPS -0.33 2022-12-31: EPS -0.37 2023-03-31: EPS -0.87 2023-06-30: EPS -0.60 2023-09-30: EPS -1.03 2023-12-31: EPS -0.06 2024-03-31: EPS -0.98 2024-06-30: EPS -0.45 2024-09-30: EPS -0.95 2024-12-31: EPS -0.66 2025-03-31: EPS -0.93 2025-06-30: EPS 0.70 2025-09-30: EPS -0.80 2025-12-31: EPS -1.41 2026-03-31: EPS -0.56 2026-06-30: EPS -0.69 0M 247M 494M $M -1.55 -0.39 0.77 201720182019202020212022202320242025202606/26 Revenue EPS

Quarterly figures, revenue up to 10 years back; EPS split-adjusted, early quarters hidden when not calibrable

Quarterly free cash flow
-815M-160M494M 20162017201820192020202120222023202420252026
Latest quarter $-815M (2026-03-31)

FCF = operating cash flow − capex, computed from SEC XBRL; banks/insurers have no standard cash-flow structure and are hidden

As of 2026-06-30 · SEC filings (XBRL)

Email me the next update

2026 Q3 holdings are due 2026-11-16. We will email you when the refreshed lists are live.